THE GREEN TEA POLYPHENOL EPIGALLOCATECHIN-3-GALLATE (EGCG) RESTORES CDKL5-DEPENDENT SYNAPTIC DEFECTS IN VITRO AND IN VIVO

The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo

CDKL5 deficiency disorder (CDD) is a rare X-linked neurodevelopmental disorder that is characterised by early-onset seizures, intellectual disability, gross motor impairment, and autistic-like features.CDD is caused by mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene that encodes a serine/threonine kinase with a predominant expression i

read more



Genetic epidemiology using whole genome sequencing and haplotype networks revealed the linkage of SARS-CoV-2 infection in nosocomial outbreak

Summary: Background: A characteristic feature of SARS-CoV-2 is Lifestyle its ability to transmit from pre- or asymptomatic patients, complicating the tracing of infection pathways and causing outbreaks.Despite several reports that whole genome sequencing (WGS) and haplotype networks are useful for epidemiologic analysis, little is known about their

read more